Chondrogenesis, joint formation, and cartilage metabolism

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

JAWS coordinates chondrogenesis and synovial joint positioning.

Properly positioned synovial joints are crucial to coordinated skeletal movement. Despite their importance for skeletal development and function, the molecular mechanisms that underlie joint positioning are not well understood. We show that mice carrying an insertional mutation in a previously uncharacterized gene, which we have named Jaws (joints abnormal with splitting), die perinatally with ...

متن کامل

Roles of microRNAs in prenatal chondrogenesis, postnatal chondrogenesis and cartilage-related diseases

Cartilage has limited repair and regeneration capacity, thus damage of cartilage often results in its dysfunction and even chronic diseases like osteoarthritis (OA). Chondrogenesis induced by tissue-engineering methods is essential to treating cartilage-related diseases. MicroRNAs (miRNAs) are a class of small non-coding single-stranded RNAs which exert their biological effects by binding to th...

متن کامل

Autologous collagen-induced chondrogenesis: single-stage arthroscopic cartilage repair technique.

Autologous collagen-induced chondrogenesis is a novel, single-staged arthroscopic cartilage repair technique using microdrilling and atelocollagen or fibrin gel application under carbon dioxide insufflation. Atelocollagen is a highly purified type I collagen obtained following the treatment of skin dermis with pepsin and telopeptide removal, making it nonimmunogenic. In this procedure, atelocol...

متن کامل

Matrix Effect on Chondrogenesis: Implication on Cartilage Repair

Several million people suffer from joint cartilage damage with very debilitating conditions. Once damaged, cartilage is a tissue that does not restore itself. Techniques such as micro-fracture, autogenous or allogenous osteochondral transplantation, and autologous chondrocyte implantation may be done to repair cartilage and relieve the patients’ symptoms. The environmental factors’ effect on th...

متن کامل

Calcium signalling in chondrogenesis: implications for cartilage repair.

Undifferentiated mesenchymal stem cells (MSCs) represent an important source for cell-based tissue regeneration techniques that require differentiation towards specific lineages, including chondrocytes. Chondrogenesis, the process by which committed mesenchymal cells differentiate into chondrocytes, is controlled by complex but not yet completely understood mechanisms that involve many componen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2012

ISSN: 1478-6354

DOI: 10.1186/ar3712